To simplify the expression -5(2x - 3y + 6z - 10), we apply the distributive property, which states that a(b + c) = ab + ac. Here, we distribute -5 to each term inside the parentheses.

Step 1: Distribute -5 to 2x:
-5 * 2x = -10x

Step 2: Distribute -5 to -3y:
-5 * (-3y) = 15y

Step 3: Distribute -5 to 6z:
-5 * 6z = -30z

Step 4: Distribute -5 to -10:
-5 * (-10) = 50

Now, we combine all the results from the distribution:
-10x + 15y - 30z + 50. This is the simplified expression.