Hugo Van der Goes was a prominent Northern Renaissance painter known for his meticulous attention to detail in portraits, capturing the essence of his subjects with precision. Hans Holbein the Younger was renowned for his portraits of the English court, particularly those of King Henry VIII and his family, showcasing his skill in rendering likenesses and intricate details. Matthias Grünewald is best known for his work on the Isenheim Altarpiece, which features profound religious symbolism and reflects late medieval artistic traditions, emphasizing emotional and spiritual themes in his art.